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Health and Safe Food

Equipment for liquid chromatography
Equipment composition HPLC system, 1260 Infinity II LC System, Agilent
UHPLC system, 1290 Infinity II LC System, Agilent

Presentation of equipment

The 1260 Infinity II LC system is a HPLC system ensuring performance, reliability and robustness. The binary pump with integrated degasser can reach up to 600 bars in the column. The system enables repeated thorough rinsing of the injection needle by means of which the possibility of “carryover” is reduced to less than 10 ppm. The flexibility of the system is reflected in the multi-column thermostat which enables efficient handling of up to four chromatographic columns and efficient temperature control.

The HPLC 1260-1 Infinity II system with VWD detector records spectra from 190 to 950 nm by capturing data up to 120 Hz with a set of diodes and an adjustable slot. Time programmable switching of wavelengths ensures optimal sensitivity and selectivity for various applications. The HPLC 1260-2 Infinity II LC system includes an UV detector with two wavelengths, which enables capturing data up to 120 Hz.

The LC 1290 Infinity II system is a chromatographic system with ultra high resolution and market-leading capacity. The system provides a high chromatographic resolution between components in the sample, a low “carryover” (less than 10 ppm) and a fast pump enabling pumping up to four mobile phases at pressures up to 1300 bars and with a flow rate of up to 5 mL/min. The Intelligent System Emulation Technology (ISET) enables the transfer of chromatographic methods, regardless of the LC brand and ensures fixed retention times of compounds and peak separation. The detector with a set of diodes and an adjustable slot enables recording of UV spectra from 190 to 950 nm with capturing data up to 120 Hz.

Equipment supplier Chemass d.o.o., Merilni sistemi, https://www.chemass.si/

Equipment keeper

Prof. Dr Zoran Novak, zoran.novak@um.si

UM, Faculty of Chemistry and Chemical Engineering

Equipment location UM, Faculty of Chemistry and Chemical Engineering UM, Smeatova ulica 17, room D2-302
                   
Gas chromatograph with mass selective detector and flame-ionization detector

Presentation of equipment

The Shimadzu GCMS-QP2020 NX gas chromatograph is equipped with a mass selective detector (MS) and flame ionization detector (FID). Samples can be put into the gas chromatograph with the help of the so-called headspace injection, liquid sample injection, or solid phase microextraction. It is equipped with the AOC 6000 autosampler that makes work with the instrument simpler. The AOC 6000 has an analysis capacity of 162 liquid samples and 45 gas samples. There are also two separate split/splitless injectors built-in, one for entering samples to the MS system and the other for entering samples to the FID system. Thus, two chromatographic columns can be installed in the instrument at the same time. The oven of the chromatographic instrument is equipped with a light which makes it easier to switch the column. The instrument is equipped with an adapter that enables switching the chromatographic column without stopping the vacuum.

Equipment supplier

KEMOMED d.o.o., Brnčičeva ulica 31, 1231 Ljubljana-Črnuče, http://www.kemomed.si/​

Equipment keeper

Assist. David Majer, david.majer@um.si

UM, Faculty of Chemistry and Chemical Engineering

Equipment location

UM, Faculty of Chemistry and Chemical Engineering, Smeatova ulica 17, Laboratory for Analytical Chemistry and Industrial Analysis, room D2-204

                   
Supporting analytical equipment

Presentation of equipment

Beside measurement of pH and ORP, the SevenExcellence pH meter S400 also supports ISFET technology. Calibration of the pH meter is system controlled, which enables preciser measurements and calibration. The entire workflow from entering data and analysing samples to archiving data is transparent and efficient.

The Excellence D4 density meter offers fast and reliable density measurements with automatic temperature control from 0 to 95 °C and with an accuracy of up to 0.0001 g/cm³. The system enables the user easy application. The entire work process can be started with a click, including sampling, measuring, rinsing and drying. Automation of the work process saves time and reduces costs. The system automatically detects bubbles on the system and therefore eliminates errors in sampling. The integrated temperature regulator enables fast heating and cooling of the measuring cell to ensure precise density measurements.

The XPR10 analytical balance enables weighing from a minimum of 1.5 mg to a maximum of 10.1 g with a readability of 1 µg. The guaranteed reproducibility of results is evaluated to 0.6 µg. The balance sensor enables contactless control of the balance door which reduces possible contamination.

The XPR206DR/M analytical balance includes functions ensuring that all conditions for correct weighing are met. The system is equipped with a patented function enabling the detection of electrostatic charge on the samples and the container. The XPR balance ensures weighing of extremely small quantities of a sample from a minimum of 10 mg with an accuracy of 0.005 mg.

The XSR4002S analytical balance enables precise weighing with a capacity of up to 4.1 kg and a resolution of 0.01 g. The robust performance of the balance allows for its application in various weighing conditions. The built-in technology enables weighing during draft without a draft shield and at the same time provides faster results.

The MP55 apparatus for measuring the melting point offers simultaneous determination of up to three melting points or melting areas or up to two melting points of the slip at temperatures up to 570 °F/300 °C. The system heats up with 0.1 – 20 °C/min and can reach a temperature of 300 °C in three minutes.

The HX204 moisture analyser with fast halogen heating ensures precise and  reproducible results of measuring moisture in a sample with an accuracy of 0.001 % MC (0.1 mg). The instrument enables drying at temperatures between 40 °C and 230 °C and determining moisture content in a range of 0.01–100 % MC. The maximum capacity of the moisture analyser is 201 g.

Equipment supplier Mettler Toledo, https://www.mt.com/si/sl/home.html

Equipment keeper

Klara Žvab, mag. inž. kem. teh.

UM, Faculty of Chemistry and Chemical Engineering

Equipment location

UM, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor

room D2-302 (Excellence D4 density meter, SevenExcellence pH meter S400, T7 titrator, XPR206DR/M balance, XPR10/M balance), room D1-006 ( XSR4002S analytical balance, MP55 apparatus for measuring the melting point, HX204 moisture analyser)

                    

 

                    

Dissolution system

Presentation of equipment

The 708-DS dissolution system is a modular system designed for manual and automated testing of dissolution of active substances. The heating apparatus uses the water bath. The instrument can be configured for use with baskets or paddles. It is equipped with eight containers with a capacity from 100 ml to 2 L. Parameters can be measured with the help of a motor distributor and a sample station for dissolution, which contains a temperature and sample probe. Containers are covered with lids that prevent the evaporation of the solvent and sample. The system is equipped with the Dosage Delivery Module (DDM) enabling a precise and simultaneous dropping of samples or sequential dosing at a pre-defined interval.

As part of the extension of the 708-DS dissolution system, the latter is equipped with the 850-DS automatic sampling station and the Cary 60 UV-Vis detector. The 850-DS sampling station enables automated sampling from the dissolution system. The rotating piston pump withdraws the sample, filters it and archives for future HPLC and UV analysis. The Cary 60 UV-Vis detector uses a xenon bulb for operation. It takes the sample from the 708-DS dissolution system at a pre-defined interval and measures it sequentially. Each dissolution container is connected with two separate sampling tubes and a flow cuvette which prevents sample contamination. Flow cuvettes have different optical paths from 0.2 to 10 mm. The system offers eight measuring points for flow cuvettes.

Equipment supplier Merel d.o.o., https://www.merel.si/
Equipment keeper

Asisst. Dr Gabrijela Horvat, univ. dipl. inž. kem. tehnol., gabriela.horvat@um.si

UM, Faculty of Chemistry and Chemical Engineering

Equipment Location UM, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, room D2-0001
                   
Upright confocal microscope for single- and multi-photon optophysiology in conditions from in vitro to in vivo

Presentation of equipment

  • single- and multi-photon confocal applications, epifluorescence applications, translucent light applications;
  • Super Z Galvo stage;
  • lenses: water- oil immersion objective lenses 16X (NA 0.8), water immersion 25X (NA 1.00), water immersion 40X (NA 1.1), water immersion 63X (NA 1.20).
  • digital camera 2.8 M, 40 images per second;
  • diode laser 405 nm, Argon laser (458, 476, 488, 496 and 514 nm), supercontinuum pulsed single photon laser (WLL laser) with a wavelength between 470 and 670 nm;
  • Coherent Discovery NX IR multi-photon laser with two output beams: adjustable output beam between 660 and 1320 nm, continuous beam 1040 nm;
  • imaging unit: 7 images per second at a resolution of 512×512;
  • resonance imaging unit: 40 images per second at a resolution of 512×512;
  • PMT detector;
  • two HyD detectors;
  • two NDD (non-descanned) RLD detectors for application in multi-photon mode;
  • capturing signals accordion of second or third order;
  • FLIM microscopy;
  • software LAS X SP8, integrated for being used with a camera and confocal scanner;

Equipment supplier

Mikro+Polo d.o.o., Zagrebška cesta 22, 2000 Maribor; https://www.mikro-polo.si/
Equipment keeper

Assoc. Prof. Dr Andraž Stožer, dr. med., +386 2 2345843, andraz.stozer@um.si

UM, Faculty of Medicine, Institute of Physiology

Equipment location UM, Faculty of Medicine – Institute of Physiology, Taborska ulica 8, 2000 Maribor; room PL16

                                           

              

 

Reactors for conducting chemical and biochemical reactions

Name of equipment

Batch reactor

Continuous mixer reactor

Tubular reactor

Reactor with fixed and fluidised bed

Batch enzyme reactor

Catalytic reactor

Aerobic reactor

Anaerobic reactor

Presentation of equipment

Laboratory reactors are dedicated for studies of chemical and biochemical reactions in batch or continuous operation mode, for conducting catalyzed chemical or enzyme reactions, biological aerobic or anaerobic waste water treatment, including the software for their operation.

When conducting reactions, it is important to ensure very accurate information on initiation, digestion, kinetics, mechanism and the course of the reaction. Immediate information on the course of reactions enables better knowledge, quantification efficiency, optimization and scale-up of the process. In case of some reactors, we measure conductivity that is often used for quality control of laboratory and industrial manufacturing processes. Conductivity is one of the key physical properties of solutions by means of which we are monitoring the concentration of reaction components.

Equipment supplier

Micom Electronics d.o.o., https://www.micom.si/
Equipment keeper

Assoc. Prof. Dr Darja Pečar, darja.pecar@um.si

UM, Faculty of Chemistry and Chemical Engineering

Equipment location UM, Faculty of Chemistry and Chemical Engineering, Smetanova 17, 2000 Maribor, room D1-203A, room D1-204 and room D1-313

                                                      

                         

3D nanotomograph

Name of equipment

3D nanotomograph ZEISS Xradia 620 Versa (Carl Zeiss AG, Germany)

Presentation of equipment

The ZEISS Xradia 620 Versa nano-tomograph enables advanced, high resolution digital non-destructive visualization of material samples with various x-ray densities in the ground state and in in-situ tensile-compressive deformation based on a high-energy source of x-rays and the combination of a unique optics with two-stage magnification, which enables producing images with a resolution of 4M pixels at 16-bit depth, a minimum spatial resolution of 500 nm at the smallest available size of voxel 40 nm. At a 50 mm distance of the source from the axis of sample rotation, the guaranteed resolution amounts to 1 mm. At a wide range of accelerating voltage (30–160 kV), the high source power (25W) ensures a quality and fast capturing of sample images with a wide range of mechanical and structural properties (from hydrogels to metals and rocks) without loss of resolution. The advanced architecture of the device enables high resolution 3D imaging of larger and denser objects, non-destructive characterization of the 3D microstructure of materials under controlled perturbation in situ as well as observing the development of structures over time.

Equipment supplier

Carl Zeiss AG, https://www.zeiss.com/corporate/int/about-zeiss.html

Equipment keeper

Assoc. Prof. Dr Uroš Maver, uros.maver@um.si

UM, Faculty of Medicine, Institute of Biomedical Sciences

Equipment location

UM, Faculty of Medicine, Taborska ulica 8, Maribor, room K21

                                   

Acknowledgement

According to the open-access principle, when publishing and using results obtained with the use of RIUM research infrastructure, users and research groups are obliged to state appropriate acknowledgement as stated below:

The authors acknowledge the use of research equipment <state the name of the used research equipment RIUM>, procured within the operation “Upgrading national research infrastructures – RIUM”, which was co-financed by the Republic of Slovenia and the European Union from the European Regional Development Fund.

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